With advancement of medicine over past few decades, varieties of treatment modalities have been developed for both cancerous and precancerous lesions in skin diseases. Topical and oral medications are available. Non surgical treatment modalities include destruction with cryogens electrodessication & curettage, chemical peeling agents and medical therapy with 5 fluorouracil including retinoids.
For chemoprevention of skin malignancies systemic and topical retinoids have been used. Oral retinoids have been found to be highly effective in treatment of actinic keratoses. Due to longer half life and teratogenic effect of etretinate it is no longer available in USA. In patients with the increased risk of skin malignancies from congenital disorders, high dose of isotretinoin can be used. It has beneficial effects in xenoderma pigmentosa and nevoid basal cell carcinoma syndrome. However, toxicity may develop with its long term use.
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